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Effects of Brassicaceae Isothiocyanates on Prostate Cancer

AuthorsNovío, Silvia; Cartea González, María Elena ; Soengas Fernández, María del Pilar ; Freire-Garabal, Manuel; Núñez-Iglesias, María Jesús
Issue Date12-May-2016
PublisherMultidisciplinary Digital Publishing Institute
CitationMolecules 21 (5): 626 (2016)
AbstractDespite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management of this disease requires developing better anticancer agents with greater efficacy and fewer side effects. Nature is a large source for the development of chemotherapeutic agents, with more than 50% of current anticancer drugs being of natural origin. Isothiocyanates (ITCs) are degradation products from glucosinolates that are present in members of the family <i>Brassicaceae</i>. Although they are known for a variety of therapeutic effects, including antioxidant, immunostimulatory, anti-inflammatory, antiviral and antibacterial properties, nowadays, cell line and animal studies have additionally indicated the chemopreventive action without causing toxic side effects of ITCs. In this way, they can induce cell cycle arrest, activate apoptosis pathways, increase the sensitivity of resistant PCa to available chemodrugs, modulate epigenetic changes and downregulate activated signaling pathways, resulting in the inhibition of cell proliferation, progression and invasion-metastasis. The present review summarizes the chemopreventive role of ITCs with a particular emphasis on specific molecular targets and epigenetic alterations in <i>in vitro</i> and <i>in vivo</i> cancer animal models.
Publisher version (URL)http://doi.org/10.3390/molecules21050626
Identifiersdoi: 10.3390/molecules21050626
Appears in Collections:(MBG) Artículos
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