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http://hdl.handle.net/10261/149171
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dc.contributor.author | Lozano, María Dolores | - |
dc.contributor.author | Tasset, Inmaculada | - |
dc.contributor.author | Muñoz-Serrano, Andrés | - |
dc.contributor.author | Alonso Moraga, Ángeles | - |
dc.contributor.author | Haro Bailón, Antonio de | - |
dc.date.accessioned | 2017-05-06T05:19:51Z | - |
dc.date.available | 2017-05-06T05:19:51Z | - |
dc.date.issued | 2016-01-18 | - |
dc.identifier | doi: 10.3390/nu8010048 | - |
dc.identifier.citation | Nutrients 8 (1): 48 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/149171 | - |
dc.description.abstract | Nowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of <i>Borago officinalis</i> L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The <i>in vivo Drosophila</i> Somatic Mutation and Recombination Test <i>(</i>SMART) and <i>in vitro</i> HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. <i>B. officinalis</i> and the tested compounds possess antigenotoxic activity. Moreover, <i>B. officinalis</i> wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC<sub>50</sub> values of 0.49 and 0.28 mg·mL<sup>−1</sup> for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC<sub>50</sub> = 0.07 and 0.04 mM respectively). <i>B. officinalis</i> exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that <i>B. officinalis</i> may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant. | - |
dc.description.sponsorship | We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI). | - |
dc.description.sponsorship | We are grateful to C. Gómez-Díaz (S.C.A.I., University of Córdoba, Spain) for supplying HL-60 cell line. This work was supported by the Andalusian Government (Research Project PAI 07-AGR-02759). We thank Eileen Brophy for the grammatical revision of the text. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/nu8010048 | - |
dc.relation.publisherversion | https://doi.org/10.3390/nu8010048 | - |
dc.date.updated | 2017-05-06T05:19:51Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 26797631 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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nutrients-08-00048.pdf | 1,32 MB | Adobe PDF | Visualizar/Abrir |
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