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dc.contributor.authorLozano, María Dolores-
dc.contributor.authorTasset, Inmaculada-
dc.contributor.authorMuñoz-Serrano, Andrés-
dc.contributor.authorAlonso Moraga, Ángeles-
dc.contributor.authorHaro Bailón, Antonio de-
dc.date.accessioned2017-05-06T05:19:51Z-
dc.date.available2017-05-06T05:19:51Z-
dc.date.issued2016-01-18-
dc.identifierdoi: 10.3390/nu8010048-
dc.identifier.citationNutrients 8 (1): 48 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/149171-
dc.description.abstractNowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of <i>Borago officinalis</i> L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The <i>in vivo Drosophila</i> Somatic Mutation and Recombination Test <i>(</i>SMART) and <i>in vitro</i> HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. <i>B. officinalis</i> and the tested compounds possess antigenotoxic activity. Moreover, <i>B. officinalis</i> wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC<sub>50</sub> values of 0.49 and 0.28 mg·mL<sup>−1</sup> for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC<sub>50</sub> = 0.07 and 0.04 mM respectively). <i>B. officinalis</i> exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that <i>B. officinalis</i> may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant.-
dc.description.sponsorshipWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI).-
dc.description.sponsorshipWe are grateful to C. Gómez-Díaz (S.C.A.I., University of Córdoba, Spain) for supplying HL-60 cell line. This work was supported by the Andalusian Government (Research Project PAI 07-AGR-02759). We thank Eileen Brophy for the grammatical revision of the text.-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleCancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants-
dc.typeartículo-
dc.identifier.doi10.3390/nu8010048-
dc.relation.publisherversionhttps://doi.org/10.3390/nu8010048-
dc.date.updated2017-05-06T05:19:51Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderJunta de Andalucía-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.identifier.pmid26797631-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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