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Title

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

AuthorsLozano, María Dolores ; Tasset, Inmaculada; Muñoz-Serrano, Andrés; Alonso-Moraga, Ángeles; Haro Bailón, Antonio de
Issue Date18-Jan-2016
PublisherMultidisciplinary Digital Publishing Institute
CitationNutrients 8 (1): 48 (2016)
AbstractNowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of <i>Borago officinalis</i> L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The <i>in vivo Drosophila</i> Somatic Mutation and Recombination Test <i>(</i>SMART) and <i>in vitro</i> HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. <i>B. officinalis</i> and the tested compounds possess antigenotoxic activity. Moreover, <i>B. officinalis</i> wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC<sub>50</sub> values of 0.49 and 0.28 mg·mL<sup>−1</sup> for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC<sub>50</sub> = 0.07 and 0.04 mM respectively). <i>B. officinalis</i> exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that <i>B. officinalis</i> may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant.
Publisher version (URL)https://doi.org/10.3390/nu8010048
URIhttp://hdl.handle.net/10261/149171
DOI10.3390/nu8010048
Identifiersdoi: 10.3390/nu8010048
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