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Título: | ACE-Inhibitory and Antioxidant Activities of Peptide Fragments Obtained from Tomato Processing By-Products Fermented Using Bacillus subtilis: Effect of Amino Acid Composition and Peptides Molecular Mass Distribution |
Autor: | Moayedi, Ali; Mora, Leticia CSIC ORCID; Aristoy, María Concepción CSIC ORCID; Hashemi, Maryam; Safari, Mohammad; Toldrá Vilardell, Fidel CSIC ORCID | Palabras clave: | Fermentation Bioactive peptides Size exclusion chromatography MALDI-TOF |
Fecha de publicación: | 26-jul-2016 | Editor: | Springer Nature | Citación: | Applied Biochemistry and Biotechnology 181 (1): 48-64 (2017) | Resumen: | The effects of amino acid composition and peptide molecular mass on ACE-inhibitory and antioxidant activities of protein fragments obtained from tomato waste fermented using Bacillus subtilis were evaluated. The addition of B. subtilis increased the relative amounts of aromatic and positively-charged amino acids which have been described to influence the biological activities of peptide fragments. IC50 values of hydrolysates for ACE-inhibitory and 2, 2′-diphenyl-1-picrylhydrazyl (DPPH) scavenging activities were found to be 1.5 and 8.2 mg/mL, respectively. Size-exclusion chromatography (SEC) pattern of the hydrolysate indicated the breakdown of parent proteins to smaller peptides with molecular weights mainly below 1400 Da. MALDI-TOF mass spectrometry analysis revealed that the highest ACE-inhibitory activity was due to peptides showing molecular mass range 500–800 Da, while the most active antioxidant peptides were found to be mainly at the two different peptide weight ranges 500–800 Da and 1200–1500 Da. | Versión del editor: | http://dx.doi.org/10.1007/s12010-016-2198-1 | URI: | http://hdl.handle.net/10261/149126 | DOI: | 10.1007/s12010-016-2198-1 | ISSN: | 0273-2289 |
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App Biochem Biotech 2017 181-48-64.pdf | Artículo principal | 1,2 MB | Adobe PDF | Visualizar/Abrir |
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