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Título

Bimodal atomic force microscopy imaging of isolated antibodies in air and liquids

AutorMartínez, N. F.; Lozano, José R.; Herruzo, Elena T. ; García-Pérez, Fernando ; Richter, C.; Sulzbach, T.; García García, Ricardo
Palabras claveAFM
Bimodal AFM
Fecha de publicación12-ago-2008
EditorInstitute of Physics Publishing
CitaciónNanotechnology 19 (2008)
ResumenWe have developed a dynamic atomic force microscopy (AFM) method based on the simultaneous excitation of the first two flexural modes of the cantilever. The instrument, called a bimodal atomic force microscope, allows us to resolve the structural components of antibodies in both monomer and pentameric forms. The instrument operates in both high and low quality factor environments, i.e., air and liquids. We show that under the same experimental conditions, bimodal AFM is more sensitive to compositional changes than amplitude modulation AFM. By using theoretical and numerical methods, we study the material contrast sensitivity as well as the forces applied on the sample during bimodal AFM operation.
Versión del editorhttp://dx.doi.org/ 10.1088/0957-4484/19/38/384011
URIhttp://hdl.handle.net/10261/14884
DOI10.1088/0957-4484/19/38/384011
ISSN0957-4484
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