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Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC)

AuthorsCasaso Díaz, Antonio; Túnez Fiñana, Isaac; Mata Granados, José María; Ruiz Méndez, Mª Victoria ; Dorado, Gabriel; Romero Sánchez, María Concepción; Navarro Valverde, Cristina; Quesada Gómez, José Manuel
KeywordsOlive-pomace oil distillate
Mesenchymal stem-cells
Issue Date3-Feb-2017
CitationExperimental Gerontology 90: 71-78 (2017)
AbstractAging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Interestingly, a novel olive-pomace physical treatment to generate olive oil also yields by-products rich in functional antioxidants. Thus, diet of postmenopausal women was supplemented for two months with one of such by-products (distillate 6; D6), being rich in squalene. After treatment, serum from such women showed reduced both lipidic peroxidation and oxidized low-density lipoprotein (LDL). Besides, vitamin E and coenzyme Q10 levels increased. Furthermore, culture medium containing 10% of such serum both increased osteoblastogenesis and reduced adipogenesis in human MSC from bone marrow. Therefore, highly antioxidant by-products like D6 may represent a relevant source for development of functional products, for both prevention and treatment of degenerative pathologies associated with aging, like osteoporosis.
Description40 Páginas; 3 Figuras; 3 Tablas
Publisher version (URL)http://dx.doi.org/10.1016/j.exger.2017.01.024
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