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Relevance of endoplasmic reticulum stress cell signaling in liver cold ischemia reperfusion injury

AutorFolch-Puy, Emma ; Panisello, Arnau; Oliva, Joan; López, Alexandre; Castro Benítez, Carlos; Adam, René; Roselló-Catafau, Joan
Palabras claveUnfolded protein response
Endoplasmic reticulum stress
Liver ischemia reperfusion injury
Orthotopic liver transplantation
University Wisconsin (UW) solution
Institut Georges Lopez-1 (IGL-1) solution
Fecha de publicación25-may-2016
EditorMolecular Diversity Preservation International
CitaciónInternational Journal of Molecular Sciences 17 (2016)
ResumenThe endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic reticulum stress (ERS). This can be triggered by many physiopathological conditions such as alcoholic steatohepatitis, insulin resistance or ischemia-reperfusion injury. The cell reacts to ERS by initiating a defensive process known as the unfolded protein response (UPR), which comprises cellular mechanisms for adaptation and the safeguarding of cell survival or, in cases of excessively severe stress, for the initiation of the cell death program. Recent experimental data suggest the involvement of ERS in ischemia/reperfusion injury (IRI) of the liver graft, which has been considered as one of major problems influencing outcome after liver transplantation. The purpose of this review is to summarize updated data on the molecular mechanisms of ERS/UPR and the consequences of this pathology, focusing specifically on solid organ preservation and liver transplantation models. We will also discuss the potential role of ERS, beyond the simple adaptive response and the regulation of cell death, in the modification of cell functional properties and phenotypic changes.
Versión del editorhttps://doi.org/10.3390/ijms17060807
Identificadoresdoi: 10.3390/ijms17060807
issn: 1422-0067
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