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http://hdl.handle.net/10261/148757
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dc.contributor.author | Podlesniy, Petar | - |
dc.contributor.author | Trullas, Ramón | - |
dc.date.accessioned | 2017-04-24T11:47:49Z | - |
dc.date.available | 2017-04-24T11:47:49Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier | doi: 10.1016/j.jalz.2015.12.011 | - |
dc.identifier | issn: 1552-5279 | - |
dc.identifier.citation | Alzheimer's and Dementia 12: 546-555 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/148757 | - |
dc.description.abstract | Introduction Low content of cell-free mitochondrial DNA (mtDNA) in cerebrospinal fluid (CSF) is a biomarker of early stage Alzheimer's disease (AD), but whether mtDNA is altered in a rapid neurodegenerative dementia such as Creutzfeldt-Jakob disease is unknown. Methods CSF mtDNA was measured using digital polymerase chain reaction (dPCR) in two independent cohorts comprising a total of 112 patients diagnosed with sporadic Creutzfeldt-Jakob disease (sCJD), probable AD, or non-Alzheimer's type dementia. Results Patients with AD exhibit low mtDNA content in CSF compared with patients diagnosed with sCJD or with non-Alzheimer's type dementias. The CSF concentration of mtDNA does not correlate with Aβ, t-tau, p-tau, and 14-3-3 protein levels in CSF. Discussion Low-CSF mtDNA is not a consequence of brain damage and allows the differential diagnosis of AD from sCJD and other dementias. These results support the hypothesis that mtDNA in CSF is a pathophysiological biomarker of AD. | - |
dc.description.sponsorship | This work has been funded by the Ministerio de Economia y Competitividad of Spain (grants:SAF2011-23550, SAF2014-56644-R) and by the Instituto Carlos III (grant: PI2013/08-3) from Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas to R.T., by the Neurodegenerative Disease Research (JPND-DEMTEST: Biomarker based diagnosis of rapidly progressive dementias-optimization of diagnostic protocols, 01ED1201A), by the Competence Network for Neurodegenerative Dementia (Kompetenznetzwerk Degenerative Demenzen, KNDD) and by the Bundesministerium für Bildung und Forschung (BMBF) and by the Alzheimer-Forschungs-Initiative e.V. (AFI 12851) to I.Z. | - |
dc.publisher | Elsevier | - |
dc.relation.isversionof | Postprint | - |
dc.rights | closedAccess | - |
dc.subject | Mitochondrial DNA | - |
dc.subject | Cerebrospinal fluid | - |
dc.subject | Creutzfeldt-Jakob disease | - |
dc.subject | Digital PCR | - |
dc.subject | Biomarkers | - |
dc.subject | Alzheimer's disease | - |
dc.title | Mitochondrial DNA differentiates Alzheimer's disease from Creutzfeldt-Jakob disease | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.jalz.2015.12.011 | - |
dc.relation.publisherversion | https://doi.org/10.1016/j.jalz.2015.12.011 | - |
dc.date.updated | 2017-04-24T11:47:50Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Federal Ministry of Education and Research (Germany) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002347 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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