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ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer

AutorCedó, Lídia; García-León, Annabel; Santos, David; Martínez-Cignoni, Melanie Raquel; López-Vilaró, Laura; Lerma, Enrique; Escolà-Gil, Joan Carles; Blanco-Vaca, Francisco
Fecha de publicación3-nov-2016
EditorNature Publishing Group
CitaciónScientific Reports 6: 36387 (2016)
ResumenLow levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification.
Versión del editorhttps://doi.org/10.1038/srep36387
URIhttp://hdl.handle.net/10261/148596
DOI10.1038/srep36387
Identificadoresdoi: 10.1038/srep36387
issn: 2045-2322
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