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http://hdl.handle.net/10261/148550
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pflueger, Iris | es_ES |
dc.contributor.author | Charrat, Coralie | es_ES |
dc.contributor.author | Ortiz-Mellet, Carmen | es_ES |
dc.contributor.author | García Fernández, José Manuel | es_ES |
dc.contributor.author | Di Giorgio, Christophe | es_ES |
dc.contributor.author | Benito, Juan M. | es_ES |
dc.date.accessioned | 2017-04-20T08:35:28Z | - |
dc.date.available | 2017-04-20T08:35:28Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1039/c6ob01882c | - |
dc.identifier | issn: 1477-0520 | - |
dc.identifier.citation | Organic and Biomolecular Chemistry 14: 10037- 10049 (2016) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/148550 | - |
dc.description.abstract | Exhaustive structure-efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined or polydisperse nature of the formulations. Facial amphiphiles based on rigid cage-type molecular scaffolds offer unique possibilities towards these studies. Taking advantage of regioselective functionalization schemes, we have synthesized a library of cationic cyclodextrin (CD) derivatives combining a range of hydrophilic and lipophilic domains. We have scrutinized how the hydrophilic-lipophilic balance (HLB) around the CD scaffold determines their self-assembly capabilities and the DNA binding and release abilities of the corresponding CD : DNA nanocomplexes (CDplexes). These features have been ultimately correlated with their capabilities to deliver a reporter luciferase-encoding pDNA into COS-7 cells. The ensemble of results demonstrates that fine tuning of the HLB is critical to induce compaction of DNA by the CD-based facial amphiphiles into transfection-productive CDplexes. | - |
dc.publisher | Royal Society of Chemistry (UK) | es_ES |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | en_EN |
dc.title | Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1039/c6ob01882c | - |
dc.embargo.terms | 2017-09-25 | - |
dc.date.updated | 2017-04-20T08:35:28Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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cyclodextrin.pdf | 3 MB | Adobe PDF | Visualizar/Abrir |
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