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Title

The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo

AuthorsCabana, Laura ; Fontcuberta, Josep ; Tobias, Gerard
KeywordsWalled carbon nanotubes
Asbestos-like pathogenicity
Iron-oxide nanoparticles
MRI constrast agents
Drug-delivery
Toxicity
Mice
Functionalization
Biodistribution
Purification
Issue Date1-Jun-2016
PublisherWiley-VCH
CitationSmall 12(21): 2893-2905 (2016)
AbstractCarbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts. Keywords
DescriptionCabana, Laura et al.
Publisher version (URL)http://dx.doi.org/10.1002/smll.201502721
URIhttp://hdl.handle.net/10261/148526
DOI10.1002/smll.201502721
ISSN1613-6810
Appears in Collections:(ICMAB) Artículos
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