English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/148518
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation

AutorBejaoui, Mohamed ; Pantazi, Eirini ; Folch-Puy, Emma ; Panisello, Arnau; Calvo, María; Pasut, Gianfranco; Rimola, Antoni; Navasa, Miquel; Adam, René; Roselló-Catafau, Joan
Directorhttps://doi.org/10.1155/2015/794287
Fecha de publicación12-ago-2015
EditorHindawi Publishing Corporation
CitaciónBioMed Research International: 794287 (2015)
ResumenIschemia reperfusion injury (IRI) leads to significant tissue damage in liver surgery. Polyethylene glycols (PEGs) are water soluble nontoxic polymers that have proved their effectiveness against IRI. The objective of our study was to investigate the potential protective effects of intravenous administration of a high molecular weight PEG of 35 kDa (PEG 35) in steatotic livers subjected to cold ischemia reperfusion. In this study, we used isolated perfused rat liver model to assess the effects of PEG 35 intravenous administration after prolonged cold ischemia (24 h, 4°C) and after reperfusion (2 h, 37°C). Liver injury was measured by transaminases levels and mitochondrial damage was determined by confocal microscopy assessing mitochondrial polarization (after cold storage) and by measuring glutamate dehydrogenase activity (after reperfusion). Also, cell signaling pathways involved in the physiopathology of IRI were assessed by western blot technique. Our results show that intravenous administration of PEG 35 at 10 mg/kg ameliorated liver injury and protected the mitochondria. Moreover, PEG 35 administration induced a significant phosphorylation of prosurvival protein kinase B (Akt) and activation of cytoprotective factors e-NOS and AMPK. In conclusion, intravenous PEG 35 efficiently protects steatotic livers exposed to cold IRI.
URIhttp://hdl.handle.net/10261/148518
DOI10.1155/2015/794287
Identificadoresdoi: 10.1155/2015/794287
issn: 2314-6141
Aparece en las colecciones: (IIBB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Protective Effect of Intravenous-Bejaoui.pdf2,12 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.