English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/148506
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging

AutorSerpell, Christopher J.; Martincic, Markus; Kierkowicz, Magdalena; Tobias, Gerard ; Davis, Benjamin G.
Palabras claveChemical tools
Fluorescence imaging
Molecular medicine
Nanobiotechnology
Organelles
Fecha de publicación26-oct-2016
EditorNature Publishing Group
CitaciónNature Communications 7: 13118 (2016)
ResumenThe desire to study biology in situ has been aided by many imaging techniques. Among these, X-ray fluorescence (XRF) mapping permits observation of elemental distributions in a multichannel manner. However, XRF imaging is underused, in part, because of the difficulty in interpreting maps without an underlying cellular ‘blueprint’; this could be supplied using contrast agents. Carbon nanotubes (CNTs) can be filled with a wide range of inorganic materials, and thus can be used as ‘contrast agents’ if biologically absent elements are encapsulated. Here we show that sealed single-walled CNTs filled with lead, barium and even krypton can be produced, and externally decorated with peptides to provide affinity for sub-cellular targets. The agents are able to highlight specific organelles in multiplexed XRF mapping, and are, in principle, a general and versatile tool for this, and other modes of biological imaging.
DescripciónSerpell, Christopher J. et al.
Versión del editorhttp://dx.doi.org/10.1038/ncomms13118
URIhttp://hdl.handle.net/10261/148506
DOI10.1038/ncomms13118
ISSN2041-1723
Aparece en las colecciones: (ICMAB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Serpell_NatComm_2016_editorial.pdfArtículo principal1,67 MBAdobe PDFVista previa
Visualizar/Abrir
Serpell_NatComm_2016_suppl_editorial.pdfInformación suplementaria23,07 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.