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Hydrazones as Singular Reagents in Asymmetric Organocatalysis

AuthorsRetamosa Hernández, María Gracia; Matador, Esteban; Monge, David; Lassaletta, José M. ; Fernández, Rosario
Issue Date2016
PublisherJohn Wiley & Sons
CitationChemistry - A European Journal 22: 13430- 13445 (2016)
AbstractThis Minireview summarizes strategies and developments regarding the use of hydrazones as reagents in asymmetric organocatalysis, their distinct roles in nucleophile–electrophile, cycloaddition, and cyclization reactions. The key structural elements governing the reactivity of these reagents in a preferred pathway will be discussed, as well as their different interactions with organocatalysts, leading to diverse activation modes. Along these studies, the synthetic equivalence of N-monoalkyl, N,N-dialkyl, and N-acyl hydrazones with several synthons is also highlighted. Emphasis is also put on the mechanistic studies performed to understand the observed reactivities. Finally, the functional group transformations performed from the available products has also been analyzed, highlighting the synthetic value of these methodologies, which served to access numerous families of valuable multifunctional compounds and nitrogen-containing heterocycles.
Identifiersdoi: 10.1002/chem.201602430
issn: 1521-3765
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