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dc.contributor.authorXue, Yali-
dc.contributor.authorPrado-Martinez, Javier-
dc.contributor.authorManuel, Marc de-
dc.contributor.authorHernández-Rodríguez, Jessica-
dc.contributor.authorLobón, Irene-
dc.contributor.authorMarqués-Bonet, Tomàs-
dc.contributor.authorScally, Aylwyn-
dc.date.accessioned2017-04-19T09:54:55Z-
dc.date.available2017-04-19T09:54:55Z-
dc.date.issued2015-04-10-
dc.identifierdoi: 10.1126/science.aaa3952-
dc.identifierissn: 1095-9203-
dc.identifier.citationScience 348(6231): 242-245 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/148489-
dc.description.abstractMountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival. © 2015, American Association for the Advancement of Science. All rights reserved.-
dc.description.sponsorshipSupported by Royal Society grant RG130105 (A.S.), Wellcome Trust grants 098051 (Q.A., Y.C., V.N., L.P., M.A.Q., M.S., C.T.-S., Y.X., B.Y.) and 099769/Z/12/Z (V.N.), NIH grant HG002385 (E.E.E.), a European Research Council Starting Grant (260372), and Ministerio de Ciencia e Innovacion grant BFU2011-28549 (T.M.-B.).-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isversionofPostprint-
dc.rightsclosedAccess-
dc.titleMountain gorilla genomes reveal the impact of long-term population decline and inbreeding-
dc.typeartículo-
dc.identifier.doi10.1126/science.aaa3952-
dc.relation.publisherversionhttps://doi.org/10.1126/science.aaa3952-
dc.date.updated2017-04-19T09:54:55Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderNational Institutes of Health (US)-
dc.contributor.funderWellcome Trust-
dc.contributor.funderRoyal Society (UK)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100004440es_ES
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