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http://hdl.handle.net/10261/148434
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Manzanares, Paloma | es_ES |
dc.contributor.author | Salom, Juan B. | es_ES |
dc.contributor.author | García Tejedor, Aurora | es_ES |
dc.contributor.author | Fernández-Musoles, Ricardo | es_ES |
dc.contributor.author | Ruiz-Giménez, Pedro | es_ES |
dc.contributor.author | Gimeno Alcañiz, José Vicente | es_ES |
dc.date.accessioned | 2017-04-18T10:54:50Z | - |
dc.date.available | 2017-04-18T10:54:50Z | - |
dc.date.issued | 2015-06-15 | - |
dc.identifier.citation | Food and Function 6(8) : 2440-2452 (2015) | es_ES |
dc.identifier.issn | 2042-6496 | - |
dc.identifier.uri | http://hdl.handle.net/10261/148434 | - |
dc.description.abstract | Hypertension is one of the most important causes of cardiovascular and renal morbidity and mortality, and it represents a serious health problem in Western countries. Over the last few decades scientific interest in food-derived antihypertensive peptides has grown as an alternative to drugs in the control of systemic blood pressure. Most of these peptides target the angiotensin I-converting enzyme (ACE) but emerging evidence points to other antihypertensive mechanisms beyond ACE inhibition. The milk protein lactoferrin (LF) is a good source of orally active antihypertensive peptides the characterization of which, including ex vivo functional assays and in vivo approaches, shows that they might act on several molecular targets. This review summarizes the mechanisms of action underlying the blood pressure-lowering effects of LF-derived peptides, focusing on their interaction with different components of the renin-angiotensin (RAS) and endothelin (ET) systems. The ability of LF-derived peptides to modify the expression of genes encoding proteins involved in the nitric oxide (NO) pathway and prostaglandin synthesis is also described. | es_ES |
dc.description.sponsorship | Work on the mechanism of action of LF-derived peptides has been supported by grants AGL2004-04522, AGL2007-64672/ALI and AGL2010-21009 from ‘Ministerio de Educación y Ciencia’-FEDER, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063 and RETICS RD06/0026/2006 and RD12/0014/0004 from ‘Instituto de Salud Carlos III’. Aurora García-Tejedor, Ricardo Fernández-Musoles and Pedro Ruiz-Giménez were funded by predoctoral fellowships from ‘Ministerio de Educación y Ciencia’ (BES-2011-044424, BES-2008-004472 and BES-2005-10382, respectively). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (UK) | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Food-derived antihypertensive peptides | es_ES |
dc.subject | Renin-angiotensin system (RAS) | es_ES |
dc.subject | Endothelin system | es_ES |
dc.title | Unraveling the mechanisms of action of lactoferrin-derived antihypertensive peptides: ACE inhibition and beyond | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1039/c5fo00580a | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/c5fo00580a | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Manzanares-FF2015.pdf | Artículo principal | 575,78 kB | Adobe PDF | Visualizar/Abrir |
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