English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/148434
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Unraveling the mechanisms of action of lactoferrin-derived antihypertensive peptides: ACE inhibition and beyond

AutorManzanares, Paloma ; Salom, Juan B.; García Tejedor, Aurora ; Fernández-Musoles, Ricardo ; Ruiz-Giménez, Pedro ; Gimeno Alcañiz, José Vicente
Palabras claveHypertension
Food-derived antihypertensive peptides
Renin-angiotensin system (RAS)
Endothelin system
Fecha de publicación15-jun-2015
EditorRoyal Society of Chemistry (Great Britain)
CitaciónFood and Function 6(8) : 2440-2452 (2015)
ResumenHypertension is one of the most important causes of cardiovascular and renal morbidity and mortality, and it represents a serious health problem in Western countries. Over the last few decades scientific interest in food-derived antihypertensive peptides has grown as an alternative to drugs in the control of systemic blood pressure. Most of these peptides target the angiotensin I-converting enzyme (ACE) but emerging evidence points to other antihypertensive mechanisms beyond ACE inhibition. The milk protein lactoferrin (LF) is a good source of orally active antihypertensive peptides the characterization of which, including ex vivo functional assays and in vivo approaches, shows that they might act on several molecular targets. This review summarizes the mechanisms of action underlying the blood pressure-lowering effects of LF-derived peptides, focusing on their interaction with different components of the renin-angiotensin (RAS) and endothelin (ET) systems. The ability of LF-derived peptides to modify the expression of genes encoding proteins involved in the nitric oxide (NO) pathway and prostaglandin synthesis is also described.
Versión del editorhttp://dx.doi.org/10.1039/c5fo00580a
URIhttp://hdl.handle.net/10261/148434
DOI10.1039/c5fo00580a
ISSN2042-6496
Aparece en las colecciones: (IATA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Manzanares-FF2015.pdfArtículo principal575,78 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.