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dc.contributor.authorGarcía Tejedor, Auroraes_ES
dc.contributor.authorCastelló-Ruiz, Maríaes_ES
dc.contributor.authorGimeno Alcañiz, José Vicentees_ES
dc.contributor.authorManzanares, Palomaes_ES
dc.contributor.authorSalom, Juan B.es_ES
dc.date.accessioned2017-04-18T10:40:39Z-
dc.date.available2017-04-18T10:40:39Z-
dc.date.issued2015-04-11-
dc.identifier.citationJournal of Functional Foods 15: 294-300 (2015)es_ES
dc.identifier.issn1756-4646-
dc.identifier.urihttp://hdl.handle.net/10261/148431-
dc.description.abstractNovel peptides with antihypertensive effects in SHR rats have previously been identified in lactoferrin (LF) hydrolysates. To investigate their in vivo antihypertensive mechanism, we have assessed the blood pressure lowering effects of two of these LF-derived peptides (RPYL and DPYKLRP) in Wistar rats subjected to either angiotensin I- or angiotensin II-induced hypertension. Blood pressure was measured by the tail-cuff method, hypertension was induced by subcutaneous infusion of angiotensins, and then captopril, valsartan or LF-derived peptides orally administered. Angiotensin I- and angiotensin II-induced hypertension were reversed by captopril and valsartan, respectively. RPYL and DPYKLRP reversed angiotensin I-induced hypertension, while DPYKLRP but not RPYL produced a modest reversion of angiotensin II-elicited hypertension. Neither RPYL nor DPYKLRP modified normotension. Thus, in vivo ACE inhibition is involved in the antihypertensive effects of LF-derived peptides like RPYL and DPYKLRP, while inhibition of AT1 receptor-mediated vasoconstriction plays a less relevant role.es_ES
dc.description.sponsorshipThis work was supported by grant AGL2010-21009 from ‘Ministerio de Educación y Ciencia – FEDER’, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063 and RETICS INVICTUS RD12/0014/0004 from ‘Instituto de Salud Carlos III’. A. García-Tejedor is recipient of a predoctoral fellowship from ‘Ministerio de Educación y Ciencia’ (BES-2011-044424).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectAntihypertensive peptideses_ES
dc.subjectLactoferrin-derived peptideses_ES
dc.subjectAngiotensin-induced hypertensiones_ES
dc.subjectWistar rates_ES
dc.subjectIn vivo ACE inhibitiones_ES
dc.subjectRenin angiotensin systemes_ES
dc.titleIn vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I- and angiotensin II-induced hypertension in Wistar ratses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.jff.2015.03.039-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jff.2015.03.039es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
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