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http://hdl.handle.net/10261/148431
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | García Tejedor, Aurora | es_ES |
dc.contributor.author | Castelló-Ruiz, María | es_ES |
dc.contributor.author | Gimeno Alcañiz, José Vicente | es_ES |
dc.contributor.author | Manzanares, Paloma | es_ES |
dc.contributor.author | Salom, Juan B. | es_ES |
dc.date.accessioned | 2017-04-18T10:40:39Z | - |
dc.date.available | 2017-04-18T10:40:39Z | - |
dc.date.issued | 2015-04-11 | - |
dc.identifier.citation | Journal of Functional Foods 15: 294-300 (2015) | es_ES |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | http://hdl.handle.net/10261/148431 | - |
dc.description.abstract | Novel peptides with antihypertensive effects in SHR rats have previously been identified in lactoferrin (LF) hydrolysates. To investigate their in vivo antihypertensive mechanism, we have assessed the blood pressure lowering effects of two of these LF-derived peptides (RPYL and DPYKLRP) in Wistar rats subjected to either angiotensin I- or angiotensin II-induced hypertension. Blood pressure was measured by the tail-cuff method, hypertension was induced by subcutaneous infusion of angiotensins, and then captopril, valsartan or LF-derived peptides orally administered. Angiotensin I- and angiotensin II-induced hypertension were reversed by captopril and valsartan, respectively. RPYL and DPYKLRP reversed angiotensin I-induced hypertension, while DPYKLRP but not RPYL produced a modest reversion of angiotensin II-elicited hypertension. Neither RPYL nor DPYKLRP modified normotension. Thus, in vivo ACE inhibition is involved in the antihypertensive effects of LF-derived peptides like RPYL and DPYKLRP, while inhibition of AT1 receptor-mediated vasoconstriction plays a less relevant role. | es_ES |
dc.description.sponsorship | This work was supported by grant AGL2010-21009 from ‘Ministerio de Educación y Ciencia – FEDER’, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063 and RETICS INVICTUS RD12/0014/0004 from ‘Instituto de Salud Carlos III’. A. García-Tejedor is recipient of a predoctoral fellowship from ‘Ministerio de Educación y Ciencia’ (BES-2011-044424). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Antihypertensive peptides | es_ES |
dc.subject | Lactoferrin-derived peptides | es_ES |
dc.subject | Angiotensin-induced hypertension | es_ES |
dc.subject | Wistar rat | es_ES |
dc.subject | In vivo ACE inhibition | es_ES |
dc.subject | Renin angiotensin system | es_ES |
dc.title | In vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I- and angiotensin II-induced hypertension in Wistar rats | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.jff.2015.03.039 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.jff.2015.03.039 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Garcia-Tejedor-JFF2015-Invivo.pdf | Artículo principal | 254,27 kB | Adobe PDF | Visualizar/Abrir |
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