English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/148105
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

S6 protein kinase activates Juvenile Hormone and vitellogenin production in the cockroach Blattella germanica

AutorAbrisqueta, Marc ; Süren-Castillo, Songül; Maestro, José L.
Palabras claveBlattella germanica
Insulin, juvenile hormone
Nutritional signalling
S6K
TOR
Vitellogenin
Fecha de publicaciónmar-2017
EditorJohn Wiley & Sons
CitaciónPhysiological Entomology 42(1): 10–16 (2017)
ResumenNutritional status regulates different processes, such as growth and development, through TOR (target of rapamycin) and insulin receptor signalling pathways. The ribosomal S6 protein kinase (S6K) is a downstream element of both pathways. Using cDNA from the German cockroach Blattella germanica (L.), two S6K isoform sequences (BgS6K) are cloned. The long isoform differs from the short one by the insertion of a 22-amino acid duplication, involving the key phosphorylation position Thr390. As a result of this, the long isoform presents a new, potentially regulatory phosphorylation site. RNA interference knockdown of both BgS6K isoforms induces an increase in the length of the last nymphal instar, together with a reduction in the mRNA levels of a number of enzymes of the Juvenile Hormone biosynthetic pathway in the corpora allata, vitellogenin mRNA levels in the fat body and basal oocyte length. Thus, BgS6K is important for nymphal development and is necessary for the full induction of Juvenile Hormone synthesis and vitellogenin production in adult females.
Versión del editorhttps://doi.org/10.1111/phen.12156
URIhttp://hdl.handle.net/10261/148105
DOI10.1111/phen.12156
ISSN0307-6962
E-ISSN1365-3032
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
S6K_activates_Abrisqueta.pdf433,14 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.