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Title: | Synthesis of overlapping fibrin citrullinated peptides and their use for diagnosing rheumatoid arthritis |
Authors: | Pérez Rodríguez, María L.; Gómara Elena, María José ![]() ![]() ![]() |
Keywords: | Citrulline Diagnosis Enzyme-linked immunosorbent assay Fibrin Rheumatoid arthritis Synthetic peptides |
Issue Date: | Oct-2006 |
Publisher: | Blackwell Publishing |
Citation: | Chemical Biology and Drug Design 68(4): 194-200 (2006) |
Abstract: | With the aim of developing a new enzyme-linked immunosorbent assay test to detect autoantibodies in the sera of rheumatoid arthritis patients with a high sensitivity and specificity using synthetic citrullinated peptides of fibrin (which is abundant in rheumatoid synovium) as antigenic substract, peptides belonging to α- and β-fibrin chains were selected by computer-aided prediction of antigenicity and epitope mapping and synthesized in solid phase. We analysed by enzyme-linked immunosorbent assay 133 sera from patients with well-characterized rheumatic diseases, including 67 patients with rheumatoid arthritis. The results of the immunoassays reported highlight the usefulness of fibrin-related peptides in rheumatoid arthritis diagnosis and, especially, the ability and specificity of the [Cit621,627,630]α-fibrin(617–631) (αfib617) peptide sequence to recognize the autoantibodies that are present in rheumatoid arthritis patients. |
Description: | 7 pages, 2 figures.-- PMID: 17105483 [PubMed]. |
Publisher version (URL): | http://dx.doi.org/10.1111/j.1747-0285.2006.00438.x |
URI: | http://hdl.handle.net/10261/14810 |
DOI: | http://dx.doi.org/10.1111/j.1747-0285.2006.00438.x |
ISSN: | 1747-0277 |
E-ISSN: | 1747-0285 |
Appears in Collections: | (IQAC) Artículos |
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