English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/148098
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Mechanisms of iron sensing and regulation in the yeast Saccharomyces cerevisiae

AuthorsMartínez Pastor, M. Teresa; Perea García, Ana ; Puig, Sergi
KeywordsIron homeostasis
Iron deficiency
Fe-S cluster synthesis
Yeast
Saccharomyces cerevisiae
Aft1
Yap5
Issue Date17-Mar-2017
PublisherSpringer
CitationWorld Journal of Microbiology and Biotechnology (2017) 33: 75
AbstractIron is a redox active element that functions as an essential cofactor in multiple metabolic pathways, including respiration, DNA synthesis and translation. While indispensable for eukaryotic life, excess iron can lead to oxidative damage of macromolecules. Therefore, living organisms have developed sophisticated strategies to optimally regulate iron acquisition, storage and utilization in response to fluctuations in environmental iron bioavailability. In the yeast Saccharomyces cerevisiae, transcription factors Aft1/Aft2 and Yap5 regulate iron metabolism in response to low and high iron levels, respectively. In addition to producing and assembling iron cofactors, mitochondrial iron-sulfur (Fe/S) cluster biogenesis has emerged as a central player in iron sensing. A mitochondrial signal derived from Fe/S synthesis is exported and converted into an Fe/S cluster that interacts directly with Aft1/Aft2 and Yap5 proteins to regulate their transcriptional function. Various conserved proteins, such as ABC mitochondrial transporter Atm1 and, for Aft1/Aft2, monothiol glutaredoxins Grx3 and Grx4 are implicated in this iron-signaling pathway. The analysis of a wide range of S. cerevisiae strains of different geographical origins and sources has shown that yeast strains adapted to high iron display growth defects under iron-deficient conditions, and highlighted connections that exist in the response to both opposite conditions. Changes in iron accumulation and gene expression profiles suggest differences in the regulation of iron homeostasis genes.
Publisher version (URL)http://dx.doi.org/10.1007/s11274-017-2215-8
URIhttp://hdl.handle.net/10261/148098
DOI10.1007/s11274-017-2215-8
ISSN0959-3993
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Martinez-Pastor-WJMB2017.pdfArtículo principal1,84 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.