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Nanoobjects formed by ionic PAMAM dendrimers: hydrophilic/lipophilic modulation and encapsulation properties

AutorFedeli, Elisabetta; Hernández-Ainsa, Silvia; Lancelot, Alexandre; González-Pastor, Rebeca; Calvo, Pilar; Sierra, Teresa; Serrano, José Luis
Fecha de publicación2015
EditorRoyal Society of Chemistry (Great Britain)
CitaciónSoft Matter 11(30): 6009-6017 (2015)
ResumenIn this paper, we present the preparation and properties of some ionic PAMAM derivatives, which combine hydrophilic and lipophilic carboxylic acid chains as counter-ions for all protonable inner and outer amino groups. The amphiphilic nature of the final ionic codendrimers and, hence, their self-assembling features can be modulated by using different ratios between hydrophilic and lipophilic chains. In the bulk, these new materials self-organize into smectic A liquid crystal phases. In water, they self-assemble into different types of nano-objects depending on the molecular composition. The study of the morphology of these nano-structures, their cytotoxicity and their capability to encapsulate a lipophilic anticancer drug are reported herein. Some of these nanoobjects are non-cytotoxic and present good drug trapping ability, which make them interesting nanocarriers for applications in nanotechnology and biomedicine.
URIhttp://hdl.handle.net/10261/147919
DOI10.1039/c5sm01153a
Identificadoresdoi: 10.1039/c5sm01153a
e-issn: 1744-6848
issn: 1744-683X
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