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Título: | Investigating the role of shape on the biological impact of gold nanoparticles in vitro |
Autor: | Tian, Furong; Pino González de la Higuera, Pablo del; Pelaz, Beatriz; Conde, João; Fuente, Jesús M. de la CSIC ORCID; Stoeger, Tobias | Palabras clave: | Caspases Biocompatibility Reactive oxygen species Nanotoxicology Nanoparticle shape Lung epithelial cells Gold nanoparticles CD95 (APO-1/Fas) Cell death Cathepsin-B |
Fecha de publicación: | 2015 | Editor: | Future Medicine | Citación: | Nanomedicine 10(17): 2643-2657 (2015) | Resumen: | [Aim]: To investigate the influence of gold nanoparticle geometry on the biochemical response of Calu-3 epithelial cells. [Materials & methods]: Spherical, triangular and hexagonal gold nanoparticles (GNPs) were used. The GNP-cell interaction was assessed via atomic absorption spectroscopy (AAS) and transmission electron microscopy (TEM). The biochemical impact of GNPs was determined over 72 h at (0.0001-1 mg/ml). [Results]: At 1 mg/ml, hexagonal GNPs reduced Calu-3 viability below 60%, showed increased reactive oxygen species production and higher expression of proapoptotic markers. A cell mass burden of 1:2:12 as well as number of GNPs per cell (2:1:3) was observed for spherical:triangular:hexagonal GNPs. [Conclusion]: These findings do not suggest a direct shape-toxicity effect. However, do highlight the contribution of shape towards the GNP-cell interaction which impacts upon their intracellular number, mass and volume dose. | URI: | http://hdl.handle.net/10261/147749 | DOI: | 10.2217/nnm.15.103 | Identificadores: | doi: 10.2217/nnm.15.103 e-issn: 1748-6963 issn: 1743-5889 |
Aparece en las colecciones: | (ICMA) Artículos |
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