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Investigating the role of shape on the biological impact of gold nanoparticles in vitro

AutorTian, Furong; Pino González de la Higuera, Pablo del; Pelaz, Beatriz; Conde, João; Fuente, Jesús M. de la; Stoeger, Tobias
Palabras claveCaspases
Biocompatibility
Reactive oxygen species
Nanotoxicology
Nanoparticle shape
Lung epithelial cells
Gold nanoparticles
CD95 (APO-1/Fas)
Cell death
Cathepsin-B
Fecha de publicación2015
EditorFuture Medicine
CitaciónNanomedicine 10(17): 2643-2657 (2015)
Resumen[Aim]: To investigate the influence of gold nanoparticle geometry on the biochemical response of Calu-3 epithelial cells. [Materials & methods]: Spherical, triangular and hexagonal gold nanoparticles (GNPs) were used. The GNP-cell interaction was assessed via atomic absorption spectroscopy (AAS) and transmission electron microscopy (TEM). The biochemical impact of GNPs was determined over 72 h at (0.0001-1 mg/ml). [Results]: At 1 mg/ml, hexagonal GNPs reduced Calu-3 viability below 60%, showed increased reactive oxygen species production and higher expression of proapoptotic markers. A cell mass burden of 1:2:12 as well as number of GNPs per cell (2:1:3) was observed for spherical:triangular:hexagonal GNPs. [Conclusion]: These findings do not suggest a direct shape-toxicity effect. However, do highlight the contribution of shape towards the GNP-cell interaction which impacts upon their intracellular number, mass and volume dose.
URIhttp://hdl.handle.net/10261/147749
DOI10.2217/nnm.15.103
Identificadoresdoi: 10.2217/nnm.15.103
e-issn: 1748-6963
issn: 1743-5889
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