English
español
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/147711
Share/Impact:
Statistics |
![]() ![]() ![]() |
|
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |||
|
Title: | Gold nanoparticle-siRNA mediated oncogene knockdown at RNA and protein level, with associated gene effects |
Authors: | Hernandez, Yulán; Conde, João; Baptista, Pedro V.; Fuente, Jesús M. de la; Berry, Catherine Cecilia |
Issue Date: | 2015 |
Publisher: | Future Medicine |
Citation: | Nanomedicine 10(16): 2513-2525 (2015) |
Abstract: | [Aims]: RNAi is a powerful tool for gene silencing that can be used to reduce undesirable overexpression of oncogenes as a novel form of cancer treatment. However, when using RNAi as a therapeutic tool there is potential for associated gene effects. This study aimed to utilize gold nanoparticles to deliver siRNA into HeLa cells. [Results]: Knockdown of the c-myc oncogene by RNAi, at the RNA, protein and cell proliferation level was achieved, while also identifying associated gene responses. [Discussion]: The gold nanoparticles used in this study present an excellent delivery platform for siRNA, but do note associated gene changes. [Conclusion]: The study highlights the need to more widely assess the cell physiological response to RNAi treatment, rather than focus on the immediate RNA levels. |
URI: | http://hdl.handle.net/10261/147711 |
DOI: | http://dx.doi.org/10.2217/nnm.15.95 |
Identifiers: | doi: 10.2217/nnm.15.95 e-issn: 1748-6963 issn: 1743-5889 |
Appears in Collections: | (ICMA) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | ![]() View/Open |
Show full item record
Review this work
Review this work
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.