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Deciphering intracellular events triggered by mild magnetic hyperthermia in vitro and in vivo

AuthorsMoros, María; Stepien, Grazyna; Fuente, Jesús M. de la; Tortiglione, Claudia
KeywordsHeat shock proteins
Hydra vulgaris
Magnetic nanoparticles
Sublethal hyperthermia
Murine melanoma cells
Issue Date2015
PublisherFuture Medicine
CitationNanomedicine 10(14): 2167-2183 (2015)
Abstract[Aim]: To assess the cell response to magnetic nanoparticles under an alternating magnetic field by molecular quantification of heat responsive transcripts in two model systems. [Materials & methods]: Melanoma cells and Hydra vulgaris treated with magnetic nanoparticles were subjected to an alternating magnetic field or to macroscopic heating. Effect to these treatments were assessed at animal, cellular and molecular levels. [Results]: By comparing hsp70 expression following both treatments, thermotolerance pathways were found in both systems in absence of cell ablation or global temperature increment. [Conclusion]: Analysis of hsp70 transcriptional activation can be used as molecular thermometer to sense cells' response to magnetic hyperthermia. Similar responses were found in cells and Hydra, suggesting a general mechanism to the delivery of sublethal thermal doses.
DescriptionThis work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License.-- et al.
Publisher version (URL)https://doi.org/10.2217/nnm.15.70
Identifiersdoi: 10.2217/nnm.15.70
e-issn: 1748-6963
issn: 1743-5889
Appears in Collections:(ICMA) Artículos
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