English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/147442
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways

AuthorsGarmendia, Juncal ; Martí-Lliteras, Pau; Moleres, Javier ; Puig, Carmen; Bengoechea, José Antonio
KeywordsHaemophilus infl uenzae
Noncapsulated/nontypable Haemophilus infl uenzae (NTHi)
Pathogen-host interplay
Genetic diversity
Virulence phenotype
Issue Date2012
PublisherSociedad Española de Microbiología
CitationInternational Microbiology 15: 159-172 (2012)
AbstractThe human respiratory tract contains a highly adapted microbiota including commensal and opportunistic pathogens. Noncapsulated or nontypable Haemophilus influenzae (NTHi) is a human-restricted member of the normal airway microbiota in healthy carriers and an opportunistic pathogen in immunocompromised individuals. The duality of NTHi as a colonizer and as a symptomatic infectious agent is closely related to its adaptation to the host, which in turn greatly relies on the genetic plasticity of the bacterium and is facilitated by its condition as a natural competent. The variable genotype of NTHi accounts for its heterogeneous gene expression and variable phenotype, leading to differential host-pathogen interplay among isolates. Here we review our current knowledge of NTHi diversity in terms of genotype, gene expression, antigenic variation, and the phenotypes associated with colonization and pathogenesis. The potential benefits of NTHi diversity studies discussed herein include the unraveling of pathogenicity clues, the generation of tools to predict virulence from genomic data, and the exploitation of a unique natural system for the continuous monitoring of long-term bacterial evolution in human airways exposed to noxious agents. Finally, we highlight the challenge of monitoring both the pathogen and the host in longitudinal studies, and of applying comparative genomics to clarify the meaning of the vast NTHi genetic diversity and its translation to virulence phenotypes.
Publisher version (URL)http://doi.org/10.2436/20.1501.01.169
URIhttp://hdl.handle.net/10261/147442
DOIhttp://dx.doi.org/10.2436/20.1501.01.169
Identifiersissn: 1139-6709
e-issn: 1618-1905
Appears in Collections:(IDAB) Artículos
Files in This Item:
File Description SizeFormat 
haemophilus_influenzae_Garmendia.pdf316,95 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.