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http://hdl.handle.net/10261/14706
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pérez Escoda, Teresa | - |
dc.contributor.author | Ercilla, Guadalupe | - |
dc.contributor.author | Chan, Weng C. | - |
dc.contributor.author | Haro Villar, Isabel | - |
dc.date.accessioned | 2009-07-13T09:31:59Z | - |
dc.date.available | 2009-07-13T09:31:59Z | - |
dc.date.issued | 2006-04 | - |
dc.identifier.citation | Journal of Peptide Science 12(4): 267-278 (2006) | en_US |
dc.identifier.issn | 1075-2617 | - |
dc.identifier.uri | http://hdl.handle.net/10261/14706 | - |
dc.description | 12 pages, 7 figures.-- PMID: 16180243 [PubMed].-- Available online Sep 23, 2005. | en_US |
dc.description.abstract | In this work, new putative epitopes located in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry for their use in immunoassays. The antigens were obtained in linear, chimeric and cyclic forms with the main aim of improving the sensitivity of the enzyme immunoassays. Our results showed, on one hand, that the combination of different antigens seems to be necessary to ensure good sensitivity and more specificity and, on the other hand, that cyclic compounds show higher ability to recognize anti-GBV-C/HGV antibodies than its parent peptide. Furthermore, CD and FTIR have been used in conjunction to characterize the conformational changes therein with synthetic constructs that could explain their different antigenicity. | en_US |
dc.description.sponsorship | This work was supported by the MCYT Project BQU2003-0507-CO2-02. Teresa Pérez acknowledges the CSIC I3P postgraduate scholarship program for financial support. | en_US |
dc.format.extent | 311795 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | European Peptide Society | en_US |
dc.publisher | John Wiley & Sons | - |
dc.rights | closedAccess | en_US |
dc.subject | GBV-C/HGV | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Solid-phase peptide synthesis | en_US |
dc.subject | Chimeric peptides | en_US |
dc.subject | Cyclic peptides | en_US |
dc.subject | ELISA | en_US |
dc.subject | Circular dichroism | en_US |
dc.subject | Fourier transformed infrared spectroscopy | en_US |
dc.title | Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1002/psc.719 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1002/psc.719 | en_US |
dc.identifier.e-issn | 1099-1387 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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