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dc.contributor.authorPérez Escoda, Teresa-
dc.contributor.authorErcilla, Guadalupe-
dc.contributor.authorChan, Weng C.-
dc.contributor.authorHaro Villar, Isabel-
dc.date.accessioned2009-07-13T09:31:59Z-
dc.date.available2009-07-13T09:31:59Z-
dc.date.issued2006-04-
dc.identifier.citationJournal of Peptide Science 12(4): 267-278 (2006)en_US
dc.identifier.issn1075-2617-
dc.identifier.urihttp://hdl.handle.net/10261/14706-
dc.description12 pages, 7 figures.-- PMID: 16180243 [PubMed].-- Available online Sep 23, 2005.en_US
dc.description.abstractIn this work, new putative epitopes located in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry for their use in immunoassays. The antigens were obtained in linear, chimeric and cyclic forms with the main aim of improving the sensitivity of the enzyme immunoassays. Our results showed, on one hand, that the combination of different antigens seems to be necessary to ensure good sensitivity and more specificity and, on the other hand, that cyclic compounds show higher ability to recognize anti-GBV-C/HGV antibodies than its parent peptide. Furthermore, CD and FTIR have been used in conjunction to characterize the conformational changes therein with synthetic constructs that could explain their different antigenicity.en_US
dc.description.sponsorshipThis work was supported by the MCYT Project BQU2003-0507-CO2-02. Teresa Pérez acknowledges the CSIC I3P postgraduate scholarship program for financial support.en_US
dc.format.extent311795 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherEuropean Peptide Societyen_US
dc.publisherJohn Wiley & Sons-
dc.rightsclosedAccessen_US
dc.subjectGBV-C/HGVen_US
dc.subjectDiagnosisen_US
dc.subjectSolid-phase peptide synthesisen_US
dc.subjectChimeric peptidesen_US
dc.subjectCyclic peptidesen_US
dc.subjectELISAen_US
dc.subjectCircular dichroismen_US
dc.subjectFourier transformed infrared spectroscopyen_US
dc.titleAntigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGVen_US
dc.typeartículoen_US
dc.identifier.doi10.1002/psc.719-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1002/psc.719en_US
dc.identifier.e-issn1099-1387-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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