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Antigenicity of chimeric and cyclic synthetic peptides based on nonstructural proteins of GBV-C/HGV

AutorPérez, Teresa; Ercilla, Guadalupe; Chan, Weng C.; Haro Villar, Isabel
Palabras claveGBV-C/HGV
Solid-phase peptide synthesis
Chimeric peptides
Cyclic peptides
Circular dichroism
Fourier transformed infrared spectroscopy
Fecha de publicaciónabr-2006
EditorEuropean Peptide Society
John Wiley & Sons
CitaciónJournal of Peptide Science 12(4): 267-278 (2006)
ResumenIn this work, new putative epitopes located in nonstructural proteins of GBV-C/HGV were synthesized using solid-phase chemistry for their use in immunoassays. The antigens were obtained in linear, chimeric and cyclic forms with the main aim of improving the sensitivity of the enzyme immunoassays. Our results showed, on one hand, that the combination of different antigens seems to be necessary to ensure good sensitivity and more specificity and, on the other hand, that cyclic compounds show higher ability to recognize anti-GBV-C/HGV antibodies than its parent peptide. Furthermore, CD and FTIR have been used in conjunction to characterize the conformational changes therein with synthetic constructs that could explain their different antigenicity.
Descripción12 pages, 7 figures.-- PMID: 16180243 [PubMed].-- Available online Sep 23, 2005.
Versión del editorhttp://dx.doi.org/10.1002/psc.719
ISSN1075-2617 (Print)
1099-1387 (Online)
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