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Título: | Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes |
Autor: | González-Vera, Juan A. CSIC ORCID; Fueyo-González, Francisco CSIC ORCID; Alkorta, Ibon CSIC ORCID ; Peyressatre, Marion; Morris, May C.; Herranz, Rosario CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Royal Society of Chemistry (UK) | Citación: | Chemical Communications 52: 9652-9655 (2016) | Resumen: | Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25. | Versión del editor: | http://dx.doi.org/10.1039/C6CC04566A | URI: | http://hdl.handle.net/10261/146962 | DOI: | 10.1039/C6CC04566A | Identificadores: | doi: 10.1039/c6cc04566a issn: 1359-7345 e-issn: 1364-548X |
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