English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/146844
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Assessment of chlorpyrifos toxic effects in zebrafish (Danio rerio) metabolism

AuthorsGómez-Canela, Cristian ; Prats, Eva; Piña, Benjamin; Tauler, Romà
KeywordsEnvironmental pollution
LC-HRMS
Metabolomics
ROI-MCR-ALS
Zebrafish
Issue Date1-Jan-2017
PublisherElsevier
CitationEnvironmental Pollution 220: 1231-1243 (2017)
AbstractIn this work the effect of chlorpyrifos exposure on metabolic profiles of zebrafish muscle was evaluated by liquid chromatography coupled to high resolution mass spectrometry. Different chemometric tools based on the selection of Regions of Interest and on Multivariate Curve-Resolution-Alternating Least Squares are proposed for the analysis of the complex data sets generated in the different exposure experiments. Analysis of Variance Simultaneous Component Analysis of changes on metabolite peak profile areas showed significant chlorpyrifos concentration and exposure time-dependent changes, clearly differentiating between exposed and non-exposed samples and between short (2 h) and long exposure times (6 h or 24 h). The changes observed in the concentrations of 50 muscle metabolites are indicative of induction of oxidative stress, of a general disruption of neurotransmitter metabolism, and of muscle exhaustion. These three effects are intimately related to the toxicity of chlorpyrifos. © 2016 Elsevier Ltd
Publisher version (URL)10.1016/j.envpol.2016.11.010
URIhttp://hdl.handle.net/10261/146844
DOI10.1016/j.envpol.2016.11.010
Appears in Collections:(IDAEA) Artículos
Files in This Item:
File Description SizeFormat 
CHEMAGEB_36.docx1,15 MBMicrosoft Word XMLView/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.