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Título: | Nectar yeasts of the Metschnikowia clade are highly susceptible to azole antifungals widely used in medicine and agriculture |
Autor: | Álvarez-Pérez, Sergio; Vega, Clara de CSIC ORCID; Pozo, María I. CSIC; Lenaerts, Marijke; Assche, Aldo van; Herrera, Carlos M. CSIC ORCID; Jacquemym, H.; Lievens, Bart | Palabras clave: | Broth microdilution Metschnikowia clade Insect pollinators Floral nectar EUCAST Azoles |
Fecha de publicación: | 2016 | Editor: | Blackwell Publishing | Citación: | FEMS Yeast Research 16 (2016) | Resumen: | The widespread use of azole antifungals in medicine and agriculture and the resulting long-persistent residues could potentially affect beneficial fungi. However, there is very little information on the tolerance of non-target environmental fungi to azoles. In this study, we assessed the susceptibility of diverse plant- and insect-associated yeasts from the Metschnikowia clade, including several ecologically important species, to widely used medical and agricultural azoles (epoxiconazole, imazalil, ketoconazole and voriconazole). A total of 120 strains from six species were tested. Minimum inhibitory concentrations (MICs) were determined by the EUCAST broth microdilution procedure after some necessary modifications were made. The majority of species tested were highly susceptible to epoxiconazole, ketoconazole and voriconazole (>95% of strains showed MICs ≤ 0.125 mg l). Most strains were also very susceptible to imazalil, although MIC values were generally higher than for the other azoles. Furthermore, certain Metschnikowia reukaufii strains displayed a 'trailing' phenotype (i.e. showed reduced but persistent growth at antifungal concentrations above the MIC), but this characteristic was dependent on test conditions. It was concluded that exposure to azoles may pose a risk for ecologically relevant yeasts from the Metschnikowia clade, and thus could potentially impinge on the tripartite interaction linking these fungi with plants and their insect pollinators. | URI: | http://hdl.handle.net/10261/146573 | DOI: | 10.1093/femsyr/fov115 | Identificadores: | doi: 10.1093/femsyr/fov115 issn: 1567-1364 |
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