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Effects of recombinant Subolesin vaccine on tick infestations in cattle and sheep farms

AuthorsTorina, Alessandra; Fernández de Mera, Isabel G.; Moreno-Cid, Juan A. ; Caracappa, Santo; Vicente, Joaquín ; Gortázar, Christian ; Fuente, José de la
Issue Date2014
CitationTTP8 & STVM12 (2014)
Abstract[Objectives]: Several species of ticks are associated with the transmission of diseases of great impact to the human and animal health and are the most important vectors of pathogens affecting livestock. Despite the use of chemical acaricides, tick infestations continue to affect livestock worldwide. Tick vaccines have been proposed as a cost-effective and environmentally friendly alternative for tick control. This study was aimed to investigate the effect of vaccination with the candidate tick protective antigen, Subolesin, on tick infestations in both cattle and sheep livestock. [Method]: Two cattle and two sheep farms with similar geographical locations and production characteristics were randomly assigned to control and vaccinated groups. All the animals of the vaccinated groups were immunized with two doses of 1 ml containing 100 μg of the Subolesin fused to Anaplasma marginale Major Surface Protein 1a. Serum antibody titers were determined using antigen specific indirect ELISAs against Subolesin. In these farms ticks were collected, counted, weighed and classified for one year prior to and 9 months after vaccination. An antibody response against Subolesin following vaccination was observed in both farms. The percent of infested cattle was reduced by 8-fold, while in sheep a reduction of tick infestations by 63% was observed. A decrease in female tick weight by 32-55% was observed in ticks collected from both vaccinated cattle and sheep when compared to controls. [Conclusions]: These results support the efficacy of recombinant vaccines in controlling tick infestations, encouraging their use for tick control in cattle and sheep, even under multiple tick species infestations.
DescriptionResumen del póster presentado al Joint 8th International Ticks and Tick-borne Pathogens and 12th Biennial Society for Tropical Veterinary Medicine Conference, celebradas en Cape Town (Sudafrica) del 24 al 29 de agosto de 2014.-- et al.
Appears in Collections:(IREC) Comunicaciones congresos
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