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dc.contributor.authorVallverdú-Coll, Núria-
dc.contributor.authorOrtiz-Santaliestra, Manuel E.-
dc.contributor.authorMougeot, François-
dc.contributor.authorMateo, Rafael-
dc.identifier.citationSETAC North America 35th Annual Meeting (2014)-
dc.descriptionResumen del trabajo presentado al Society of Environmental Toxicology and Chemistry North America 35th Annual Meeting, celebrado en Vancouver (Canadá) del 9 al 13 de noviembre de 2014.-
dc.description.abstractThe ingestion of shot used for hunting constitutes the main cause of lead (Pb) poisoning in birds. Pb can be transferred from the mother to the eggs and then to the offspring. Birds are especially vulnerable to the immunotoxic effects of Pb during embryonic and early life, because the development of the immune function is not fully accomplished until several days after hatching. The aims of this study were to study the effects of the paternal exposure to Pb shot on the development of the immune function of their progeny through an experimental approach with chicks of red-legged partridge (Alectoris rufa) born from Pb exposed parents. To perform this experimental study, adult partridges were housed in pairs (n=86) in which either females or males were dosed with 0, 1 or 3 Pb shot. Laid eggs were artificially incubated and the development of the innate and adaptive immune functions was studied in the chicks. The innate or non-specific immune response was tested measuring phagocytic activity in fresh blood. As for the adaptive responses, cell-mediated specific response was studied using a phytohemagglutinin (PHA)-skin test, and humoral specific response was tested by haemagglutination test after two different antigens administration to assess separately T-dependent and T-independent antibody activities. Our results show that parental exposure decreased both innate and adaptive responses, affecting both cellular and humoral adaptive responses in chicks. The decrease in innate function observed in chicks at the age of 24 days was related to paternal exposure. Regarding the adaptive function, the decrease of cellular (PHA) and humoral (T-dependent and T-independent antibody production) responses observed in chicks at the age of 19 days was only related to maternal exposure. These results confirm the observations of our previous study with mallard ducklings, in which cellular immune function was negatively correlated with Pb exposure due to the maternal Pb transfer through the egg.-
dc.titleEffects of parental Pb exposure on the development of the immune function in birds-
dc.typecomunicación de congreso-
dc.description.versionPeer Reviewed-
Appears in Collections:(IREC) Comunicaciones congresos
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