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Anaplasma phagocytophilum uses similar strategies to establish infection in vertebrate hosts and tick vectors

AuthorsFuente, José de la
Issue Date2015
CitationXIX Congreso de la Sociedad Española de Parasitología (2015)
AbstractTicks are blood feeding arthropod ectoparasites that transmit pathogens causing diseases in humans and animals worldwide. Among these vector-borne pathogens, Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae) has become an important tick-borne pathogen in the United States, Europe and Asia, with increasing numbers of affected people and animals every year. The natural infection cycle of A. phagocytophilum is dependent upon the presence of infected vertebrate reservoir hosts and Ixodid tick vectors. A. phagocytophilum is an obligate intracellular Gram-negative bacterium that multiplies within a parasitophorous vacuole or morula inside tick and vertebrate cells. Tick-host-pathogen interactions have evolved trough dynamic processes involving genetic traits of hosts, pathogens and ticks that mediate their development and survival. A. phagocytophilum morulae can be easily observed in human HL-60 cells, but not in I.scapularis ISE6 cells, in which A. phagocytophilum appears highly pleomorphic, suggesting that specific strategies are devised by this bacterium when colonizing distinct hosts. However, as discussed here, molecular characterization of the host/tick-pathogen interface has provided evidences that the bacterium uses similar strategies to establish infection in vertebrate hosts and tick vectors. These strategies include remodeling of the cytoskeleton, inhibition of cell apoptosis and manipulation of the immune response. The evolution of similar strategies for A. phagocytophilum infection of vertebrate and tick cells suggest the possibility of developing strategies to control pathogen infection in both vertebrate hosts and tick vectors.
DescriptionResumen del trabajo presentado al XIX Congreso de la Sociedad Española de Parasitología (II Encuentro Internacional de Parasitólogos de España, Francia, Italia y Portugal), celebrado en Vitoria-Gasteiz del 23 al 25 de julio de 2015.
Appears in Collections:(IREC) Comunicaciones congresos
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