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Título

Acute and repeated administration of sulpiride alters Met-and Leu-enkephalin content of rat brain

AutorCeballos, María L. de ; Jenner, P.; Marsden, C. D.
Palabras clavehypothalamus
sulpiride
Leu-enkephalin
Fecha de publicación1986
EditorElsevier
CitaciónNeuroscience Letters 68: 322- 326 (1986)
ResumenFollowing acute administration of sulpiride (100 mg/kg, i.p.), Met-enkephalin levels were increased in striatum but decreased in substantia nigra and nucleus accumbens. No effect was observed in hypothalamus or frontal cortex. In contrast, Leu-enkephalin content was decreased in the nucleus accumbens but not elsewhere. Administration of sulpiride (10 or 100 mg/kg, i.p.) for 21 days, followed by 2 days drug withdrawal, caused a dose-dependent increase in Met-enkephalin in nucleus accumbens but decreases in hypothalamus and frontal cortex. No change was observed in the striatum or substantia nigra. Repeated sulpiride administration caused a decrease in Leu-enkephalin content of the hypothalamus and cortex but not elsewhere
URIhttp://hdl.handle.net/10261/145992
Identificadoresissn: 0304-3940
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