English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/145902
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Antinociceptive effects in rodents of the dipeptide Lys-Trp (Nps) and related compounds

AutorGarcía-López, M. T.; Herranz, R.; González-Muñiz, R.; Naranjo, J. R.; Ceballos, M. L. de; Rio, J. del
Palabras claveLTN produces
opioid receptors
Fecha de publicación1986
CitaciónPeptides 7: 39- 43 (1986)
ResumenIntracerebroventricular administration of the synthetic dipeptide derivative Lys-Trp (Nps) (LTN) elicits a potent and naloxone-sensitive antinociceptive effect in mice and in rats using heat and electrical current respectively as the noxious stimuli. LTN does not induce analgesia by directly acting on opioid receptors but the peptidase inhibiting activity of the new compound may account in part for the behavioral effect. LTN produces also a marked decrease in the met-enkephalin content of the periaqueductal gray suggesting a possible enkephalin releasing property. Structure-activity studies with different analogs of LTN indicate that replacement of Lys by other basic amino acids results also in compounds with a potent antinociceptive effect whereas replacement by neutral or acidic amino acids leads to a complete loss of activity.
Identificadoresdoi: null
issn: 0196-9781
Aparece en las colecciones: (IC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.