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A targeting motif involved in sodium channel clustering at the axonal initial segment

AutorGarrido Jurado, Juan José ; Giraud, P.; Carlier, E.; Fernandes, F.; Moussif, A.; Fache, M. P.; Debanne, D.
Palabras clavedevelopment and plasticity
neuronal electrogenesis
hippocampal neurons
Fecha de publicación2003
EditorAmerican Association for the Advancement of Science
CitaciónSCIENCE 300: 2091- 2094 (2003)
ResumenThe sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Nav1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Nav1.2II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, this motif may play a fundamental role in controlling electrical excitability during development and plasticity.
URIhttp://hdl.handle.net/10261/145898
DOI10.1126/science.1085167
Identificadoresdoi: 10.1126/science.1085167
issn: 0036-8075
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