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http://hdl.handle.net/10261/145647
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Marchena, Miguel | es_ES |
dc.contributor.author | Villarejo-Zori, Beatriz | es_ES |
dc.contributor.author | Zaldívar-Díez, Josefa | es_ES |
dc.contributor.author | Palomo, Valle | es_ES |
dc.contributor.author | Gil, Carmen | es_ES |
dc.contributor.author | Hernández-Sánchez, Catalina | es_ES |
dc.contributor.author | Martínez Gil, Ana | es_ES |
dc.contributor.author | De la Rosa, Enrique J. | es_ES |
dc.date.accessioned | 2017-02-23T11:17:00Z | - |
dc.date.available | 2017-02-23T11:17:00Z | - |
dc.date.issued | 2017-01-23 | - |
dc.identifier.citation | Journal of Enzyme Inhibition and Medicinal Chemistry 32 (1) 522-526 (2017) | es_ES |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.uri | http://hdl.handle.net/10261/145647 | - |
dc.description | 6 p.-5 fig. | es_ES |
dc.description.abstract | Retinitis pigmentosa (RP) is an inherited retinal dystrophy that courses with progressive degeneration of retinal tissue and loss of vision. Currently, RP is an unpreventable, incurable condition. We propose glycogen synthase kinase 3 (GSK-3) inhibitors as potential leads for retinal cell neuroprotection, since the retina is also a part of the central nervous system and GSK-3 inhibitors are potent neuroprotectant agents. Using a chemical genetic approach, diverse small molecules with different potency and binding mode to GSK-3 have been used to validate and confirm GSK-3 as a pharmacological target for RP. Moreover, this medicinal chemistry approach has provided new leads for the future disease-modifying treatment of RP. | es_ES |
dc.description.sponsorship | This work has been partially funded by the Spanish MINECO grants (SAF2012-37979-C03-01 to AM and SAF2013-41059-R to EJdlR). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Taylor & Francis | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | GSK-3 inhibitors | es_ES |
dc.subject | Retinal diseases | es_ES |
dc.subject | Retinitis pigmentosa | es_ES |
dc.subject | Glaucoma | es_ES |
dc.title | Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1080/14756366.2016.1265522 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1080/14756366.2016.1265522 | es_ES |
dc.identifier.e-issn | 1475-6374 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 28114834 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (CIB) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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J.Enz. Inhibit. Med. Chem. 2017.pdf | Artículo principal | 1,13 MB | Adobe PDF | Visualizar/Abrir |
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