English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/145614
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorVerkhovtsev, A.-
dc.contributor.authorSolov'yov, A. V.-
dc.contributor.authorSurdutovich, E.-
dc.date.accessioned2017-02-22T15:47:13Z-
dc.date.available2017-02-22T15:47:13Z-
dc.date.issued2016-06-14-
dc.identifierdoi: 10.1038/srep27654-
dc.identifierissn: 2045-2322-
dc.identifier.citationScientific Reports 6 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/145614-
dc.description10 págs.; 4 figs. 1 tab. ; Open Access funded by Creative Commons Atribution Licence 4.0-
dc.description.abstractIon-beam therapy provides advances in cancer treatment, offering the possibility of excellent dose localization and thus maximising cell-killing within the tumour. The full potential of such therapy can only be realised if the fundamental mechanisms leading to lethal cell damage under ion irradiation are well understood. The key question is whether it is possible to quantitatively predict macroscopic biological effects caused by ion radiation on the basis of physical and chemical effects related to the ion-medium interactions on a nanometre scale. We demonstrate that the phenomenon-based MultiScale Approach to the assessment of radiation damage with ions gives a positive answer to this question. We apply this approach to numerous experiments where survival curves were obtained for different cell lines and conditions. Contrary to other, in essence empirical methods for evaluation of macroscopic effects of ionising radiation, the MultiScale Approach predicts the biodamage based on the physical effects related to ionisation of the medium, transport of secondary particles, chemical interactions, thermo-mechanical pathways of biodamage, and heuristic biological criteria for cell survival. We anticipate this method to give great impetus to the practical improvement of ion-beam cancer therapy and the development of more efficient treatment protocols.-
dc.description.sponsorshipWe acknowledge the financial support received from the European Union Seventh Framework Programme (PEOPLE2013-ITN-ARGENT project) under grant agreement no. 608163.-
dc.publisherNature Publishing Group-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/608163-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleMultiscale approach predictions for biological outcomes in ion-beam cancer therapy-
dc.typeartículo-
dc.identifier.doi10.1038/srep27654-
dc.relation.publisherversionhttp://doi.org/10.1038/srep27654-
dc.date.updated2017-02-22T15:47:13Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0-
dc.contributor.funderEuropean Commission-
dc.contributor.funderSCOAP-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
Appears in Collections:(CFMAC-IFF) Artículos
Files in This Item:
File Description SizeFormat 
Multiscale.pdf845,9 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.