English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/145614
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Multiscale approach predictions for biological outcomes in ion-beam cancer therapy

AuthorsVerkhovtsev, A. ; Solov'yov, A. V.; Surdutovich, E.
Issue Date14-Jun-2016
PublisherNature Publishing Group
CitationScientific Reports 6 (2016)
AbstractIon-beam therapy provides advances in cancer treatment, offering the possibility of excellent dose localization and thus maximising cell-killing within the tumour. The full potential of such therapy can only be realised if the fundamental mechanisms leading to lethal cell damage under ion irradiation are well understood. The key question is whether it is possible to quantitatively predict macroscopic biological effects caused by ion radiation on the basis of physical and chemical effects related to the ion-medium interactions on a nanometre scale. We demonstrate that the phenomenon-based MultiScale Approach to the assessment of radiation damage with ions gives a positive answer to this question. We apply this approach to numerous experiments where survival curves were obtained for different cell lines and conditions. Contrary to other, in essence empirical methods for evaluation of macroscopic effects of ionising radiation, the MultiScale Approach predicts the biodamage based on the physical effects related to ionisation of the medium, transport of secondary particles, chemical interactions, thermo-mechanical pathways of biodamage, and heuristic biological criteria for cell survival. We anticipate this method to give great impetus to the practical improvement of ion-beam cancer therapy and the development of more efficient treatment protocols.
Description10 págs.; 4 figs. 1 tab. ; Open Access funded by Creative Commons Atribution Licence 4.0
Publisher version (URL)http://doi.org/10.1038/srep27654
Identifiersdoi: 10.1038/srep27654
issn: 2045-2322
Appears in Collections:(CFMAC-IFF) Artículos
Files in This Item:
File Description SizeFormat 
Multiscale.pdf845,9 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.