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Zera®, a novel technology for stable accumulation and easy recovery of recombinant proteins in eukaryotic protein-production hosts

AutorLlop, I.; Torrent, Maties; Marzabal, P.; Bastida, M.; Llompart, B.; Ludevid, M. Dolors
Fecha de publicación10-oct-2006
EditorBioMed Central
CitaciónMicrobial Cell Factories 2006, 5(Suppl 1):S42
ResumenFirst paragraph (this article has no abstract) Subcellular targeting of proteins in host cells is one of the most important issues in protein production. Stability, folding, and post-translational modifications depend on where proteins are sorted. Besides secretion, ER appears as an efficient compartment to accumulate proteins, as demonstrated by the frequent use of K/HDEL fused to the C-terminus of a protein to retain and accumulate recombinant proteins in the endoplasmic reticulum (ER) of the cell hosts.
URIhttp://hdl.handle.net/10261/1451
DOI10.1186/1475-2859-5-S1-S42
ISSN1475-2859
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