English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/144278
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Mapping protective epitopes in the tick and mosquito subolesin ortholog proteins

AuthorsPrudencio, Carlos Roberto; Pérez de Lastra, José Manuel ; Canales, Mario ; Villar, Margarita ; Fuente, José de la
KeywordsTick
Vaccine
Akirin
Subolesin
Mosquito
Immunology
Ixodes
Aedes
Issue Date2010
PublisherElsevier
CitationVaccine 28(33): 5398-5406 (2010)
AbstractThe tick protective antigen, subolesin, is a structural and functional ortholog of insect akirins, an evolutionary conserved group of proteins that regulate gene expression thus affecting multiple cellular processes such as digestion, immune response, reproduction and development. In this study, we searched for common protective epitopes in tick and mosquito subolesin ortolog proteins. By combining the results of peptide and phage-display libraries scan analysis with sera from protected animals with computational modeling, three different epitope types (i) linear B-cell epitopes, (ii) conformational epitopes, and (iii) conformational discontinuous epitopes were identified. The determination of conserved protective epitopes in subolesin ortologs may lead to the development of a multi-target universal vaccine directed at the control of both arthropod infestations and reduction of vector capacity to transmit pathogens.
URIhttp://hdl.handle.net/10261/144278
DOI10.1016/j.vaccine.2010.06.021
Identifiersdoi: 10.1016/j.vaccine.2010.06.021
issn: 0264-410X
e-issn: 1873-2518
Appears in Collections:(IREC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.