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Immunization of rabbits with recombinant serine protease inhibitor reduces the performance of adult female Rhipicephalus microplus

AuthorsJittapalapong, S.; Canales, Mario ; Fuente, José de la
Rhiphicephalus (Boophilus) microplus
Salivary glands
Issue Date2010
CitationTransboundary and Emerging Diseases 57(1-2): 103-106 (2010)
AbstractMolecules secreted from the tick salivary gland modulate the vertebrate host immune response, thus representing potential targets for novel tick control measures. Tick salivary gland serine protease inhibitor (Serpin) is one such molecule that may facilitate tick feeding, blood meal digestion and pathogen transmission. The objective of this study was to determine the immunogenicity and protection of recombinant Rhipicephalus (Boophilus) microplus salivary gland Serpin (rSerpin) in rabbits. Rabbits were injected with rSerpin, adjuvant or phosphate-buffered saline (PBS) alone, and challenge infested with 500 R. microplus larvae that were allowed to continuously feed and moult through the adult stage. All immunized rabbits generated antibodies to rSerpin in the second week after immunization. Ticks fed on immunized rabbits resulted in 83% reduction in adult engorgement and 34% reduction in egg mass weight compared with the PBS control. These results indicated that this tick Serpin is immunogenic to rabbits, and suggested that this vaccine candidate antigen can confer protective immunity against cattle ticks in this experimental model.
Identifiersdoi: 10.1111/j.1865-1682.2010.01108.x
issn: 1865-1674
e-issn: 1865-1682
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