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Title

Evolution of the melanocortin system

AuthorsCortés, Raúl ; Navarro, S. ; Agulleiro Gozalbo, Maria Josep ; Guillot, Raúl ; García-Herranz, Víctor; Sánchez, Elisa ; Cerdá-Reverter, José Miguel
KeywordsAGRP
ACTH
MRAP
AGOUTI
POMC
MSH
Issue DateDec-2014
PublisherElsevier
CitationGeneral and Comparative Endocrinology 209: 3-10 (2014)
AbstractThe melanocortin system is one of the most complex of the hormonal systems. It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs). Rounds of whole genome duplication events have preceded the functional and molecular diversification of the family in addition some co-evolutionary and tandem duplication processes have been proposed. The evolutionary patterns of the different partners are controversial and different hypotheses have emerged from a study of the sequenced genomes. In this review, we summarize the different evolutionary hypotheses proposed for the different melanocortin partners. © 2014 Elsevier Inc.
Publisher version (URL)https://doi.org/10.1016/j.ygcen.2014.04.005
URIhttp://hdl.handle.net/10261/144147
DOI10.1016/j.ygcen.2014.04.005
Identifiersissn: 1095-6840
Appears in Collections:(IATS) Artículos
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