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Title

Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission

AuthorsFuente, José de la ; Moreno-Cid, Juan A. ; Canales, Mario ; Villar, Margarita ; Pérez de Lastra, José Manuel ; Kocan, Katherine M.; Galindo, Ruth C. ; Almazán, Consuelo; Blouin, Edmour F.
KeywordsAkirin
RNA interference
Subolesin
Vaccine
Mite
Tick
Mosquito
Sandfly
Issue Date2011
PublisherElsevier
CitationVeterinary Parasitology 181(1): 17-22 (2011)
AbstractDiseases caused by arthropod-borne pathogens greatly impact on human and animal health. Recent research has provided evidence that tick protective antigens can be used for development of vaccines with the dual target of controlling arthropod infestations and reducing their vector capacity for pathogens. As reviewed herein, protective antigens such as subolesin/akirin, which are highly conserved across vector species, show promise for use in development of a universal vaccine for the control of arthropod infestations and the reduction of pathogen transmission. However, further research is needed in critical areas towards achieving this goal.
URIhttp://hdl.handle.net/10261/143988
DOI10.1016/j.vetpar.2011.04.018
Identifiersdoi: 10.1016/j.vetpar.2011.04.018
issn: 0304-4017
e-issn: 1873-2550
Appears in Collections:(IREC) Artículos
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