English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/143867
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

An overview on kisspeptins in European sea bass

AuthorsKah, Olivier; Escobar, Sebastián ; Espigares, F. ; Alvarado, M. V. ; Servili, Arianna; Felip, Alicia ; Gómez, Ana ; Carrillo, Manuel ; Zanuy, Silvia
Issue Date25-Jun-2015
CitationThe International Symposium on Genetics in Aquaculture XII (2015)
AbstractKisspeptin 1-10, encoded by the kiss1 gene has emerged as a major actor in the neuroendocrine regulation of the reproductive axis in mammals. Although the existence of two kiss genes (kiss1 and kiss2) and to kiss receptors (kissr1 and kissr2), issued from early whole genome duplication events, is well-documented in teleosts, the functions of kisspeptins are still very unclear in fishes. This is partly due to the existence of several models species, belonging to orders that have diverged evolutionary over a long period of time. This lecture intends to summarize the information that we have obtained in a wellstudied fish model, the European seabass (Dicentrarchus labrax) a fish of high commercial interest in Europe. In this species, the neuroanatomical distribution of kiss neurons has been studied in details showing the widespread distribution in the forebrain, notably in the habenula the preoptic area and the mediobasal hypopthalamus. This expression is subject to changes according to the reproductive activity, which is not surprising as populations of kiss neurons express estrogen receptors. Interestingly, kiss2 fibres exhibit a widespread distribution that overlaps quite well with the distribution of kissr2. Kiss1. The relationships between the kiss systems and the GnRH neurons have received much attention showing that while kissr2 are expressed in a variety of neurons, notably in somatostatinergic neurons, none of the GnRH1, GnRH2 or GnRH3 neurons was shown to express kissr2. This result is surprising as there is recent evidence that kiss2-12 given intracerebraly is able to stimulate gonadotrophin release and the expression of gnrh1. These results indicate that kissspeptins probably have a wide spectrum of actions in the brain of teleosts including some indirect actions on the reproductive axis that could involve intermediate neurons, potentially NO synthase expressing cells. On another hand, kiss1 mRNAs and kiss2 fibres are present in the pituitary where direct effects of kisspeptins on gonadotrophin release have been documented.
DescriptionComunicación presentada en The International Symposium on Genetics in Aquaculture XII, celebrado en Santiago de Compostela, España, del 21 al 27 de junio de 2015
URIhttp://hdl.handle.net/10261/143867
Appears in Collections:(IATS) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.