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http://hdl.handle.net/10261/143659
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dc.contributor.author | González-Barrios, María | es_ES |
dc.contributor.author | Fierro-González, Juan Carlos | es_ES |
dc.contributor.author | Krpelanova, Eva | es_ES |
dc.contributor.author | Mora-Lorca, José Antonio | es_ES |
dc.contributor.author | Pedrajas, José R. | es_ES |
dc.contributor.author | Peñate, Xenia | es_ES |
dc.contributor.author | Chávez, Sebastián | es_ES |
dc.contributor.author | Swoboda, Peter | es_ES |
dc.contributor.author | Jansen, Gert | es_ES |
dc.contributor.author | Miranda-Vizuete, Antonio | es_ES |
dc.date.accessioned | 2017-02-08T13:49:56Z | - |
dc.date.available | 2017-02-08T13:49:56Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | Genetics 200(4): 1363 (2015) | es_ES |
dc.identifier.issn | 0016-6731 | - |
dc.identifier.uri | http://hdl.handle.net/10261/143659 | - |
dc.description.abstract | The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the nematode Caenorhabditis elegans. For this purpose, we have dissected the promoters of the only two genes so far reported to be exclusively expressed in ASJ, trx-1 and ssu-1. We hereby identify the ASJ motif, a functional cis-regulatory bipartite promoter region composed of two individual 6 bp elements separated by a 3 bp linker. The first element is a 6 bp CG-rich sequence that presumably binds the Sp family member zinc-finger transcription factor SPTF-1. Interestingly, within the C. elegans nervous system SPTF-1 is also found to be expressed only in ASJ neurons where it regulates expression of other genes in these neurons and ASJ cell fate. The second element of the bipartite motif is a 6 bp AT-rich sequence that is predicted to potentially bind a transcription factor of the homeobox family. Together, our findings identify a specific promoter signature and SPTF-1 as a transcription factor that functions as a terminal selector gene to regulate gene expression in C. elegans ASJ sensory neurons. | es_ES |
dc.description.sponsorship | Some C. elegans strains were provided by the CGC, which is funded by the National Institutes of Health Office of Research Infrastructure Programs (P40 OD010440), and by the Japanese National Bioresource Project, which is funded by the Japanese Ministry of Education, Culture, Sport, Science and Technology. We thank Nuria Flames for advice and support and María Jesús Rodríguez-Palero and Francisco José Naranjo-Galindo for excellent technical assistance. This work was financed by grants to A.M.-V. from the Junta de Andalucía (Projects P07-CVI-02697 and P08-CVI-03629). Work in the laboratory of P.S. was supported by grants from the Swedish Research Council and the Torsten Söderberg Foundation. E.K. was supported by a grant from the European Union FP6 Marie Curie Research Training Network “EUrythron” MRTN-CT-2004-005499. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Genetics Society of America | es_ES |
dc.relation.isreferencedby | González-Barrios, María; Fierro-González, Juan Carlos; Krpelanova, Eva; Mora-Lorca, José Antonio; Pedrajas, José R.; Peñate, Xenia; Chávez, Sebastián; Swoboda, Peter; Jansen, Gert; Miranda-Vizuete, Antonio. Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans. http://doi.org/10.1534/genetics.115.176172 . http://hdl.handle.net/10261/143656 | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Caenorhabditis elegans | es_ES |
dc.subject | Thioredoxin | es_ES |
dc.subject | Promoters | es_ES |
dc.subject | ASJ neuron | es_ES |
dc.subject | SPTF-1 transcription factor | es_ES |
dc.subject | ASJ motif | es_ES |
dc.title | Corrigendum: Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1534/genetics.115.179051 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1534/genetics.115.179051 | es_ES |
dc.identifier.e-issn | 1943-2631 | - |
dc.contributor.funder | National Institutes of Health (US) | es_ES |
dc.contributor.funder | Torsten Söderberg Foundation | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | Ministry of Education, Culture, Sports, Science and Technology (Japan) | es_ES |
dc.contributor.funder | Swedish Research Council | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100007464 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001700 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 26272998 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
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