English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/143614
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Low serum uric acid concentration in Parkinson's disease in southern Spain

AuthorsJesús Maestre, Silvia; Pérez, I.; Cáceres-Redondo, María T.; Carrillo, Fátima; Carballo, Manuel; Gómez-Garre, Pilar; Mir, Pablo
KeywordsAntioxidants
Parkinson’s disease
Uric acid
Issue DateJan-2013
PublisherJohn Wiley & Sons
CitationEuropean Journal of Neurology 20(1): 208–210 (2013)
Abstract[Background and purpose] Uric acid (UA) is thought to have an antioxidant effect on the central nervous system and may also prevent cerebral damage induced by oxidative stress. Our study aimed to investigate whether patients with Parkinson's disease (PD) had lower serum UA concentrations than controls and whether UA concentration was related to clinical parameters of the disease.
[Methods] We included 161 patients with PD and 178 controls from southern Spain. UA concentration was compared between these two groups. Clinical parameters including severity of the disease were related to serum UA.
[Results] Patients with PD showed statistically significant lower serum UA concentrations than controls. Serum UA concentration was lower in patients with PD in severe stages (4 and 5) than in those in moderate stage (2) according to the modified Hoehn and Yahr scale. Other clinical parameters were not related to serum UA concentration, except for levodopa equivalent daily dose that was associated with lower serum UA concentration in men.
[Conclusions] Our study produced consistent findings that UA might have a protective effect against PD and could influence its clinical progression.
Publisher version (URL)https://doi.org/10.1111/j.1468-1331.2012.03745.x
URIhttp://hdl.handle.net/10261/143614
DOI10.1111/j.1468-1331.2012.03745.x
ISSN1351-5101
E-ISSN1468-1331
Appears in Collections:(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.