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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/143527
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dc.contributor.authorEstrada, Martín-
dc.contributor.authorPérez, Concepción-
dc.contributor.authorSoriano, Elena-
dc.contributor.authorPricl, Sabrina-
dc.contributor.authorMorales-García, José A.-
dc.contributor.authorPérez Castillo, Ana-
dc.contributor.authorRodríguez-Franco, María Isabel-
dc.date.accessioned2017-02-07T09:29:50Z-
dc.date.available2017-02-07T09:29:50Z-
dc.date.issued2016-07-
dc.identifierissn: 1756-8919-
dc.identifiere-issn: 1756-8927-
dc.identifier.citationFuture Medicinal Chemistry 8(11): 1191-1207 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/143527-
dc.descriptionet al.-
dc.description.abstract[Background]: Neurogenic agents emerge as innovative drugs for the treatment of Alzheimer's disease (AD), whose pathological complexity suggests strengthening research in the multi-target directed ligands strategy. [Results]: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: σ-1 receptor (σR), β-secretase-1 (BACE1) and acetylcholinesterase (AChE). Moreover, they show potent neurogenic properties, good antioxidant capacity and favorable CNS permeability. Molecular modeling studies on AChE, σR and BACE1 highlight relevant drug-protein interactions that may contribute to the development of new disease-modifying drugs. [Conclusion]: New lipoic-based σ agonists endowed with neurogenic, antioxidant, cholinergic and amyloid β-peptide-reducing properties have been discovered for the potential treatment of AD.-
dc.description.sponsorshipFinancial support from the Spanish Ministry of Economy and Competitiveness (MINECO, grants SAF2012-31035 and SAF2015-64948 to MIRF; grants SAF2010-16365 and SAF2014-52940-R to APC), Fundación de Investigación Médica Mutua Madrileña Automovilística (grant AP103952012 to MIRF), and Consejo Superior de Investigaciones Científicas (CSIC, grant PIE-201580E109 to MIRF) is gratefully acknowledged. ME thanks COLCIENCIAS (Colombia) for a Ph.D. fellowship. ES, and EL and SP thank CESGA (Santiago de Compostela, Spain) and CINECA (Bologna, Italy – Project SIMBIOSY) supercomputer centres, respectively, for providing access to computational resources.-
dc.publisherFuture Science-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64948-C2-1-R-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-52940-R-
dc.relation.isversionofPreprint-
dc.rightsopenAccessen_EN
dc.subjectLipoic acid-
dc.subjectAcetylcholinesterase (AChE)-
dc.subjectBeta-secretase-1 (BACE1)-
dc.subjectsigma-1 receptor (σ1R)-
dc.subjectNeurogenic properties-
dc.subjectN,N-dibenzyl(N-methyl)amine-
dc.subjectN-benzylpiperidine-
dc.subjectMulti-target directed ligands (MTDLs)-
dc.subjectAlzheimer’s disease-
dc.titleNew neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition-
dc.typeartículo-
dc.identifier.doi10.4155/fmc-2016-0036-
dc.relation.publisherversionhttps://doi.org/10.4155/fmc-2016-0036-
dc.date.updated2017-02-07T09:29:51Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderFundación Mutua Madrileña-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderColciencias (Colombia)-
dc.relation.csicSí-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008061es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.pmid27402296-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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