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dc.contributor.authorRuíz García, Lorena-
dc.contributor.authorDelgado, Susana-
dc.contributor.authorRuas-Madiedo, Patricia-
dc.contributor.authorMargolles Barros, Abelardo-
dc.contributor.authorSánchez García, Borja-
dc.date.accessioned2017-02-06T12:23:53Z-
dc.date.available2017-02-06T12:23:53Z-
dc.date.issued2016-08-03-
dc.identifierissn: 1664-302X-
dc.identifier.citationFrontiers in Microbiology 7: 1193 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/143478-
dc.description.abstractBifidobacteria are commensal microoganisms found in the gastrointestinal tract. Several strains have been attributed beneficial traits at local and systemic levels, through pathogen exclusion or immune modulation, among other benefits. This has promoted a growing industrial and scientific interest in bifidobacteria as probiotic supplements. However, the molecular mechanisms mediating this cross-talk with the human host remain unknown. High-throughput technologies, from functional genomics to transcriptomics, proteomics, and interactomics coupled to the development of both in vitro and in vivo models to study the dynamics of the intestinal microbiota and their effects on host cells, have eased the identification of key molecules in these interactions. Numerous secreted or surface-associated proteins or peptides have been identified as potential mediators of bifidobacteria-host interactions and molecular cross-talk, directly participating in sensing environmental factors, promoting intestinal colonization, or mediating a dialogue with mucosa-associated immune cells. On the other hand, bifidobacteria induce the production of proteins in the intestine, by epithelial or immune cells, and other gut bacteria, which are key elements in orchestrating interactions among bifidobacteria, gut microbiota, and host cells. This review aims to give a comprehensive overview on proteinaceous molecules described and characterized to date, as mediators of the dynamic interplay between bifidobacteria and the human host, providing a framework to identify knowledge gaps and future research needs.-
dc.description.sponsorshipThis research was funded by Grant AGL2013-44039-R from the Spanish “Plan Estatal de I+D+I.” LR has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant agreement n°624773. BS was recipient of a Ramón y Cajal postdoctoral contract from the Spanish Ministry of Economy and Competitiveness. SD is hired on a contract supported by BIO2014-55019-JIN project from the Spanish “Plan Estatal de I+D+I.”-
dc.publisherFrontiers Media-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/624773-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectHost interaction-
dc.subjectAdhesin-
dc.subjectImmunomodulation-
dc.subjectProteome-
dc.subjectBifidobacterium-
dc.titleProteinaceous molecules mediating Bifidobacterium-host interactions-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3389/fmicb.2016.01193-
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2016.01193-
dc.date.updated2017-02-06T12:23:53Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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